The dietary sweetener sucralose is a negative modulator of T cell-mediated responses.

ABSTRACT: Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years¹. Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners^2-5. In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8⁺ T cell antigen-specific responses in subcutaneous cancer models and bacterial infect

SUBMITTER: Zani F 

PROVIDER: S-EPMC10033444 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature