Association of liver fibrosis with cognitive test performance and brain imaging parameters in the UK Biobank study.

ABSTRACT:

Introduction

We hypothesized that liver fibrosis is associated with worse cognitive performance and corresponding brain imaging changes.

Methods

We examined the association of liver fibrosis with cognition and brain imaging parameters in the UK Biobank study. Liver fibrosis was assessed using the Fibrosis-4 (FIB-4) score. The primary cognitive outcome was the digit symbol substitution test (DSST); secondary outcomes were additional executive function/processing speed and memory tests. Imaging outcomes were hippocampal, total brain, and white matter hyperintensity (WMH) volumes.

Results

We included 105,313 participants with cognitive test data, and 41,982 with magnetic resonance imaging (MRI). In adjusted models, liver fibrosis was associated with worse performance on

SUBMITTER: Parikh NS 

PROVIDER: S-EPMC10033462 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature