Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex.

ABSTRACT: Neocortex is the evolutionarily newest region in the brain, and is a structure with diversified size and morphology among mammalian species. Humans have the biggest neocortex compared to the body size, and their neocortex has many foldings, that is, gyri and sulci. Despite the recent methodological advances in in vitro models such as cerebral organoids, mice have been continuously used as a model system for studying human neocortical development because of the accessibility and practicality of in vivo gene manipulation. The commonly studied neocortical region, the lateral neocortex, generally recapitulates the developmental process of the human neocortex, however, there are several important factors missing in the lateral neocortex. First, basal (outer) radial glia (bRG), which are the mai

SUBMITTER: Vaid S 

PROVIDER: S-EPMC10033555 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature