Obesity, antioxidants and negative symptom improvement in first-episode schizophrenia patients treated with risperidone.

ABSTRACT: Negative symptoms remain a main therapeutic challenge in patients with schizophrenia (SZ). Obesity is associated with more severe negative symptoms after the first episode of psychosis. Oxidative stress caused by an impaired antioxidant defense system is involved in the pathophysiology of SZ. Yet, it is unclear regarding the role of obesity and antioxidants in negative symptom improvements in SZ. Therefore, this longitudinal study was designed to assess the impact of obesity on antioxidant defenses and negative symptom improvements in first-episode SZ patients. A total of 241 medication-naive and first-episode patients with SZ were treated with risperidone for 3 months. Outcome measures including symptoms, body weight, and total antioxidant status (TAS) levels were measured at baseline and

SUBMITTER: Gao Z 

PROVIDER: S-EPMC10033648 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature