SLiM CRAB criteria revisited: temporal trends in prognosis of patients with smoldering multiple myeloma who meet the definition of ‘biomarker-defined early multiple myeloma’—a systematic review with meta-analysis

ABSTRACT: Summary

Background

Biomarker-defined patients with smoldering multiple myeloma (SMM) were included in the diagnostic category of multiple myeloma (MM) by the International Myeloma Working Group (IMWG) in 2014. This includes ≥60% bone marrow plasma cells (BMPCs), free light chain ratio (FLCratio) ≥100, and >1 MRI-defined ≥5 mm focal lesion, also called SLiM CRAB MM. We examined whether the risk of progression of SLiM CRAB MM patients to CRAB positive MM described in recent studies differs from that reported in earlier studies published before the introduction of the new diagnostic criteria.

Methods

We conducted a systematic review with meta-analysis, and included studies on Embase and PubMed (01/01/2010–01/11/2022), selecting studies with digitizable progression curves. In

SUBMITTER: Ludwig H 

PROVIDER: S-EPMC10033724 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature