Regioselective C-H alkylation of anisoles with olefins by cationic imidazolin-2-iminato scandium(iii) alkyl complexes.

ABSTRACT: A new type of rare-earth alkyl complexes supported by monoanionic imidazolin-2-iminato ligands were synthesised and structurally characterised by X-ray diffraction and NMR analyses. The utility of these imidazolin-2-iminato rare-earth alkyl complexes in organic synthesis was demonstrated by their performance in highly regioselective C-H alkylation of anisoles with olefins. With as low as 0.5 mol% catalyst loading, various anisole derivatives without ortho-substitution or 2-methyl substituted anisoles reacted with several alkenes under mild conditions, producing the corresponding ortho-Csp²-H and benzylic Csp³-H alkylation products in high yield (56 examples, 16-99% yields). Control experiments revealed that rare-earth ions, ancillary imidazolin-2-iminato

SUBMITTER: Wang S 

PROVIDER: S-EPMC10033784 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature