Rationale and design of the iCORONARY trial: improving the cost-effectiveness of coronary artery disease diagnosis.

ABSTRACT:

Background

In patients with stable coronary artery disease (CAD), revascularisation decisions are based mainly on the visual grading of the severity of coronary stenosis on invasive coronary angiography (ICA). However, invasive fractional flow reserve (FFR) is the current standard to determine the haemodynamic significance of coronary stenosis. Non-invasive and less-invasive imaging techniques such as computed-tomography-derived FFR (FFR-CT) and angiography-derived FFR (QFR) combine both anatomical and functional information in complex algorithms to calculate FFR.

Trial design

The iCORONARY trial is a prospective, multicentre, non-inferiority randomised controlled trial (RCT) with a blinded endpoint evaluation. It investigates the costs, effects and outcomes of different dia

SUBMITTER: Peper J 

PROVIDER: S-EPMC10033793 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature