Association of per- and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults.

ABSTRACT:

Background & aims

Per- and polyfluoroalkyl substances (PFAS) are widespread pollutants with demonstrated hepatotoxicity. Few studies have examined the association between PFAS and fatty liver disease (FLD) risk in an adult population.

Methods

In this cross-sectional study of participants from the 2017-2018 National Health and Nutrition Examination Survey, serum PFAS were measured, and FLD cases were ascertained by vibration-controlled transient elastography. Logistic regression models were used to examine the association between circulating PFAS levels and FLD risk. Analyses were stratified into non-alcoholic FLD and alcoholic FLD risk groups by alcohol intake status, as well as controlling for other risk factors, including personal demographics, lifestyle factors, and relat

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10033989 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature