Causal relationship between human blood omega-3 fatty acids and the risk of epilepsy: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Though omega-3 fatty acids reduce seizures in several animal models, considerable controversy exists regarding the association between omega-3 fatty acids and epilepsy in human.

Objective

To assess whether genetically determined human blood omega-3 fatty acids are causally associated with the risk of epilepsy outcomes.

Methods

We conducted a two-sample Mendelian randomization (MR) analysis by applying summary statistics of genome-wide association study datasets of both exposure and outcomes. Single nucleotide polymorphisms significantly associated with blood omega-3 fatty acids levels were selected as instrumental variables to estimate the causal effects on epilepsy. Five MR analysis methods were conducted to analyze the final results. The inverse-variance

SUBMITTER: Liang Z 

PROVIDER: S-EPMC10034028 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature