Are IL-1 family cytokines important in management of sickle cell disease in Sub-Saharan Africa patients?

ABSTRACT:

Introduction

Sickle cell disease (SCD) is the most common genetic disease found in Africa and throughout the world. It is responsible for a high rate of hemolysis, systemic inflammation, and modulation of the immune system with the involvement of immunological molecules, such as cytokines. IL-1β is a major inflammatory cytokine. IL-18 and IL-33, members of IL-1 family, also exhibit characteristics of inflammation-related cytokines. Thus, in order to contribute to the evaluation of the severity and prognosis of SCD in Africa, this study aimed to estimate the cytokine response, in particular the levels of cytokines of the IL-1 family, in sickle cell patients living in a Sub-Saharan country.

Methods

Ninety patients with a diagnosis of SCD were recruited with different hemoglobi

SUBMITTER: Siransy LK 

PROVIDER: S-EPMC10034065 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature