Association between HOMA-IR and ovarian sensitivity index in women with PCOS undergoing ART: A retrospective cohort study

ABSTRACT:

Introduction

Insulin resistance (IR) may play a central role in the pathophysiology of polycystic ovary syndrome (PCOS). Controlled ovarian stimulation (COS) in PCOS women in the setting of assisted reproductive technology (ART) is always a challenge for clinicians. However, it remains unclear whether IR in women with PCOS correlates with reduced ovarian sensitivity to exogenous gonadotropin (Gn). This study aimed to explore the association between homeostasis model assessment of insulin resistance (HOMA-IR) and ovarian sensitivity index (OSI).

Methods

In this retrospective cohort study, we explored the association between Ln HOMA-IR and Ln OSI based on smoothing splines generated by generalized additive model (GAM). Then the correlation between HOMA-IR and OSI was furthe

SUBMITTER: Li Y 

PROVIDER: S-EPMC10034104 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature