CD27⁺ microparticle interactions and immunoregulation of CD4⁺ T lymphocytes.

ABSTRACT:

Introduction

Aplasia and hematological malignancies are treated with platelet transfusions, which can have major immunomodulatory effects. Platelet concentrates (PCs) contain many immunomodulatory elements, including the platelets themselves, residual leukocytes, extracellular vesicles, such as microparticles (MPs), cytokines and other soluble elements. Two of these components, MPs and a soluble form of CD27 (sCD27), have been shown to play a particularly important role in immune system modulation. The loss of CD27 expression is an irreversible marker of terminal effector CD3⁺ T-lymphocyte (TL) differentiation, and the CD27⁺ MPs present in PCs may maintain CD27 expression on the surface of TLs, and, thus, the activation of these cells.

Methods

In this s

SUBMITTER: Cagnet L 

PROVIDER: S-EPMC10034125 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature