Latency period of aristolochic acid-induced upper urinary tract urothelial carcinoma.

ABSTRACT:

Purpose

Aristolochic acid (AA) is a carcinogen in upper urinary tract urothelial carcinoma (UTUC). This study investigated the latency period between AA exposure and UTUC development.

Materials and methods

This population-based cohort study was designed using record linkage of the National Health Insurance Research Database (NHIRD), Taiwan Cancer Registry Dataset, and cause-of-death data in Taiwan. Those aged 40-79 years were enrolled in this study. Patients who died or had renal insufficiency or UTUC before 2005 were excluded. The doses of AA exposure and rates of comorbidities between 2000 and 2005 were obtained. The Cox proportion hazard model was used to estimate the risk of UTUC between 2005 and 2016. In addition, the Cox model with time-varying coefficient of AA was us

SUBMITTER: Jhuang JR 

PROVIDER: S-EPMC10034135 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature