Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis.

ABSTRACT:

Objectives

Our objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.

Background

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established links to thrombotic and cardiovascular events. Endothelial cell infection was initially proposed to initiate vascular events; however, this paradigm has sparked growing controversy. The significance of myocardial infection also remains unclear.

Methods

Autopsy-derived cardiac tissue from control (n = 4) and COVID-19 (n = 8) patients underwent spatial transcriptomic profiling to assess differential expression patterns in myocardial and coronary vascular tissue. Our approach enabled transcriptional profi

SUBMITTER: Margaroli C 

PROVIDER: S-EPMC10034160 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature