Bioactive nutraceuticals oligo-lactic acid and fermented soy extract alleviate cognitive decline in mice in part via anti-neuroinflammation and modulation of gut microbiota.

ABSTRACT:

Introduction

Cognition decline is associated with aging and certain diseases, such as neurodegenerative or neuropsychiatric disorders, diabetes and chronic kidney disease. Inflammation/neuroinflammation is considered an important causal factor, and experimental evidence suggests that anti-inflammatory natural compounds may effectively prevent cognitive decline. The goal of this study was to evaluate the effects of two natural bioactive agents, oligo-lactic acid (LAP) and fermented soy extract (ImmunBalance, IMB), on cognition in an adenine-induced cognitive impairment mouse model and to investigate the modulation of related biomarkers.

Methods

Male C57 black mice were randomly assigned into the following experimental groups and received the corresponding treatments for 2 wee

SUBMITTER: Abdolmaleky HM 

PROVIDER: S-EPMC10034322 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature