Bromocriptine inhibits proliferation in the endometrium from women with adenomyosis.

ABSTRACT:

Objective

Bromocriptine treatment has been shown to reduce menstrual bleeding and pain in women with adenomyosis in a pilot clinical trial. The underlying mechanism contributing to the treatment effect is however unknown. The purpose of this study was to explore the effect of bromocriptine on the proliferation and migration properties of the endometrium in women with adenomyosis, by assessing cellular and molecular changes after six months of vaginal bromocriptine treatment.

Methods

Endometrial specimens were collected during the proliferative phase from women with adenomyosis (n=6) before (baseline) and after six months of treatment with vaginal bromocriptine. Immunohistochemistry was used to determine changes in the protein expression of Ki67 in the endometrium of women wi

SUBMITTER: Tang Y 

PROVIDER: S-EPMC10034369 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature