Variation in synonymous evolutionary rates in the SARS-CoV-2 genome.

ABSTRACT:

Introduction

Coronavirus disease 2019 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Influential variants and mutants of this virus continue to emerge, and more effective virus-related information is urgently required for identifying and predicting new mutants. According to earlier reports, synonymous substitutions were considered phenotypically silent; thus, such mutations were frequently ignored in studies of viral mutations because they did not directly cause amino acid changes. However, recent studies have shown that synonymous substitutions are not completely silent, and their patterns and potential functional correlations should thus be delineated for better control of the pandemic.

Methods

In this study, we estimated t

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10034387 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature