Conformational Dynamics of Poly(T) Single-Stranded DNA at the Single-Molecule Level.

ABSTRACT: The conformational dynamics of single-stranded DNA (ss-DNA) are implicated in the mechanisms of several key biological processes such as DNA replication and damage repair and have been modeled with those of semiflexible or flexible polymer. The high flexibility and customizability of ss-DNA also make it an excellent polymeric material for materials engineering. Polythymidine (poly(T)) is an excellent model ss-DNA as a flexible polymer since it does not form any secondary structure. However, only limited experimental results have been reported of poly(T) conformational dynamics with a very short length that is not relevant to the aforementioned processes and applications. Here, we provide the first experimental results of the conformational dynamics of poly(T) with lengths in the range of 1

SUBMITTER: Kim SH 

PROVIDER: S-EPMC10034556 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature