Dataset Information

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.

ABSTRACT: Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. Luminal mucus represents the initial steric and dynamic barrier to absorption. To overcome this barrier, we report the development of the RoboCap, an orally ingestible, robotic drug delivery capsule that locally clears the mucus layer, enhances luminal mixing, and topically deposits the drug payload in the small intestine to enhance drug absorption. RoboCap's mucus-clearing and churning movements are facilitated by an internal motor and by surface features that interact with small intestinal plicae circulares, villi, and mucus. Vancomycin (1.4 kilodaltons of glycopeptide) and insulin (5.8 kilodaltons of peptide) delivery mediated by RoboCap resulted in enhanced bioavailability 20- to 40-fold greater in ex vivo and in vivo swine models when compared with standard oral delivery (P < 0.05). Further, insulin delivery via the RoboCap resulted in therapeutic hypoglycemia, supporting its potential to facilitate oral delivery of drugs that are normally precluded by absorption limitations.

SUBMITTER: Srinivasan SS

PROVIDER: S-EPMC10034646 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.

Srinivasan Shriya S SS Alshareef Amro A Hwang Alexandria V AV Kang Ziliang Z Kuosmanen Johannes J Ishida Keiko K Jenkins Joshua J Liu Sabrina S Madani Wiam Abdalla Mohammed WAM Lennerz Jochen J Hayward Alison A Morimoto Josh J Fitzgerald Nina N Langer Robert R Traverso Giovanni G

Science robotics 20220928 70

Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. Luminal mucus represents the initial steric and dynamic barrier to absorption. To overcome this barrier, we report the development of the RoboCap, an orally ingestible, robotic drug delivery capsule that locally clears the mucus layer, enhances luminal mixing, and topically deposits the drug payload in the small intestine ...[more]

PMID: 36170378

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Project description:BackgroundCapsule endoscopy for visualization of the entire gastrointestinal tract is a challenge. A second-generation colon capsule endoscopy system (CCE-2) performed well in the colon and small intestine, but its utility in the upper gastrointestinal duct is not clear. We evaluated the use of the CCE-2 in the visualization of the upper gastrointestinal tract.MethodsWe performed a retrospective study and further evaluated CCE-2 images using the typical landmarks of esophagus and stomach. The two imagers located at each end of the CCE-2 system were defined as imager1 (green) and imager2 (yellow). Two endoscopists read the images, and they were blinded to the other reader's results. All of the images from the two imagers were separately reviewed.ResultsImages from 127 subjects were analyzed. This study demonstrated the comprehensive visualization of 71.7% of esophageal landmarks and 89.8% of gastric landmarks using the CCE-2. The two CCE-2 imagers were not identical, and the lighter imager (imager2, yellow) was superior to the heavier imager (imager1, green) (78% vs. 33.1%) in the stomach. Compared with the use of one imager, the use of two imagers was superior (two-imager vs. imager1, 89.8% vs. 33.1%; two-imager vs. imager2, 89.8% vs. 78%) in the stomach. Two-imager combination analysis detected a total of 160 positive findings. In contrast, single-imager analysis with imager1 and imager2 detected 133 and 137 findings, respectively. Two-imager combination analysis provided 20.3% and 16.8% more findings than imager1 and imager2, respectively. The two imagers complemented each other to detect more lesions.ConclusionsThe CCE-2 system is feasible for use in the upper gastrointestinal tract and may be considered an optional tool for upper gastrointestinal imaging. This system may represent a good choice for complete gastrointestinal duct screening. Compared with the use of one imager, the two-imager combination provided improved upper gastrointestinal tract mucosal visualization.

Dataset Information

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.

Publications

RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.

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