Comprehending the Structure, Dynamics, and Mechanism of Action of Drug-Resistant HIV Protease.

ABSTRACT: Since the emergence of the Human Immunodeficiency Virus (HIV) in the 1980s, strategies to combat HIV-AIDS are continuously evolving. Among the many tested targets to tackle this virus, its protease enzyme (PR) was proven to be an attractive option that brought about numerous research publications and ten FDA-approved drugs to inhibit the PR activity. However, the drug-induced mutations in the enzyme made these small molecule inhibitors ineffective with prolonged usage. The research on HIV PR, therefore, remains a thrust area even today. Through this review, we reiterate the importance of understanding the various structural and functional components of HIV PR in redesigning the structure-based small molecule inhibitors. We also discuss at length the currently available FDA-approved drugs a

SUBMITTER: Dakshinamoorthy A 

PROVIDER: S-EPMC10034783 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature