BASP1 promotes high glucose-induced endothelial apoptosis in diabetes via activation of EGFR signaling.

ABSTRACT:

Aims

Diabetes mellitus is a common chronic disease of glucose metabolism. Endothelial dysfunction is an early event in diabetes complicated by cardiovascular disease. This study aimed to reveal the expression of BASP1 and its biological roles in endothelial cell dysfunction in diabetes complicated by cardiovascular disease.

Materials and methods

By analyzing the databases related to diabetes complicated with coronary heart disease, BASP1 was screened out as an upregulated gene. Human umbilical vein endothelial cells (HUVECs) and primary mouse aortic endothelial cells were treated with high glucose to establish cell models of diabetes-related endothelial dysfunction, and the expression changes of BASP1 were verified by RT-qPCR, western blot, and immunofluorescence. BASP1 was

SUBMITTER: Sun F 

PROVIDER: S-EPMC10034959 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature