Dithiocarbazate ligands and their Ni(II) complexes with potential biological activity: Structural, antitumor and molecular docking study.

ABSTRACT: In the search for new metal complexes with antitumor potential, two dithiocarbazate ligands derived from 1,1,1-trifluoro-2,4-pentanedione (H₂L¹) and (H₂L²) and four Ni(II) complexes, [Ni(L¹)PPh₃] (1), [Ni(L¹)Py] (2), [Ni(L²)PPh₃] (3), and [Ni(L²)Py] (4), were successfully synthesized and investigated by physical-chemistry and spectroscopic methods. The crystal structure of the H₂L¹ and the Ni(II) complexes has been elucidated by single-crystal X-ray diffraction. The obtained structure from H₂L¹ confirms the cyclization reaction and formation of the pyrazoline derivative. The results showed square planar geometry to the metal centers, in w

SUBMITTER: Cavalcante CQO 

PROVIDER: S-EPMC10034969 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature