Early-life exposure to tobacco and childhood adiposity: Identifying windows of susceptibility.

ABSTRACT:

Background

Early-life exposure to tobacco is associated with obesity, but the most susceptible developmental periods are unknown.

Objective

To explore windows of susceptibility in a cohort of 568 mother-child pairs.

Methods

We measured seven measures of tobacco exposure (five self-reported and two biomarkers) spanning from pre-conception to age 5 years. Mothers self-reported active smoking (pre-conception, 17 weeks, and delivery) and household smokers (5 and 18 months postnatally). Cotinine was measured in maternal urine (27 weeks) and child urine (5 years). Adiposity (fat mass percentage) was measured at birth and 5 years via air displacement plethysmography. Using a multiple informant approach, we tested whether adiposity (5 years) and changes in adiposity (from bir

SUBMITTER: Moore BF 

PROVIDER: S-EPMC10035041 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature