Exposure to nonanoic acid alters small intestinal neuroendocrine tumor phenotype.

ABSTRACT:

Background

Small intestinal neuroendocrine tumors (SI-NET) are highly differentiated and genetically stable malignant tumors, yet they often present with advanced metastatic spread at the time of diagnosis. In contrast to many other types of malignant tumors, primary SI-NET are often asymptomatic and typically smaller in size compared to adjacent lymph node metastases. This study explores the hypothesis that stimulating the chemosensing olfactory receptor 51E1 (OR51E1) decreases SI-NET proliferation suggesting a mechanism that explains a difference in proliferative rate based on tumor location.

Methods

Clinical data was used to address difference in tumor size depending on location. A SI-NET tissue microarray was used to evaluate expression of OR51E1 and olfactory marker pro

SUBMITTER: Almobarak B 

PROVIDER: S-EPMC10035137 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature