The association between anticholinergic burden and mobility: a systematic review and meta-analyses.

ABSTRACT:

Background

As people age, they accumulate several health conditions, requiring the use of multiple medications (polypharmacy) to treat them. One of the challenges with polypharmacy is the associated increase in anticholinergic exposure to older adults. In addition, several studies suggest an association between anticholinergic burden and declining physical function in older adults.

Objective/purpose

This systematic review aimed to synthesise data from published studies regarding the association between anticholinergic burden and mobility. The studies were critically appraised for the strength of their evidence.

Methods

A systematic literature search was conducted across five electronic databases, EMBASE, CINAHL, PSYCHINFO, Cochrane CENTRAL and MEDLINE, from inception

SUBMITTER: Phutietsile GO 

PROVIDER: S-EPMC10035151 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature