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Photoenzymes for Radical C-C Coupling.

ABSTRACT: General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases (KREDs) are repurposed and engineered as highly efficient photoenzymes to catalyse asymmetric radical C-C couplings.

SUBMITTER: Guo R

PROVIDER: S-EPMC10035154 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Photoenzymes for Radical C-C Coupling.

Guo Rui R Chen Heyu H Yang Yang Y

Nature catalysis 20220722 7

General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases (KREDs) are repurposed and engineered as highly efficient photoenzymes to catalyse asymmetric radical C-C couplings. ...[more]

PMID: 36970248

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