Mutation and apoptosis are well-coordinated for protecting against DNA damage-inducing toxicity in Drosophila.

ABSTRACT:

Background

Apoptotic cell death is an important survival system for multicellular organisms because it removes damaged cells. Mutation is also a survival method for dealing with damaged cells in multicellular and also unicellular organisms, when DNA lesions are not removed. However, to the best of our knowledge, no reports have comprehensively explored the direct relationship between apoptosis and somatic cell mutations induced by various mutagenic factors.

Results

Mutation was examined by the wing-spot test, which is used to detect somatic cell mutations, including chromosomal recombination. Apoptosis was observed in the wing discs by acridine orange staining in situ. After treatment with chemical mutagens, ultraviolet light (UV), and X-ray, both the apoptotic frequency and

SUBMITTER: Toyoshima-Sasatani M 

PROVIDER: S-EPMC10035180 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature