CA916798 predicts poor prognosis and promotes Gefitinib resistance for lung adenocarcinoma.

ABSTRACT:

Background

Our previous studies have identified CA916798 as a chemotherapy resistance-associated gene in lung cancer. However, the histopathological relevance and biological function of CA916798 in lung adenocarcinoma (LUAD) remains to be delineated. In this study, we further investigated and explored the clinical and biological significance of CA916798 in LUAD.

Methods

The relationship between CA916798 and clinical features of LUAD was analyzed by tissue array and online database. CCK8 and flow cytometry were used to measure cell proliferation and cell cycle of LUAD after knockdown of CA916798 gene. qRT-PCR and western blotting were used to detect the changes of cell cycle-related genes after knockdown or overexpression of CA916798. The tumorigenesis of LUAD cells was evalu

SUBMITTER: He J 

PROVIDER: S-EPMC10035219 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature