Lyman-Kutcher-Burman normal tissue complication probability modeling for radiation-induced esophagitis in non-small cell lung cancer patients receiving proton radiotherapy.

ABSTRACT:

Purpose

To develop and test an Lyman-Kutcher-Burman (LKB) normal tissue complication probability (NTCP) model to predict radiation-induced esophagitis (RE) in non-small cell lung cancer (NSCLC) patients receiving passive-scattering proton therapy (PSPT).

Material and methods

We retrospectively reviewed 328 NSCLC patients receiving PSPT at our institution. Esophagitis severity was graded by physicians according to the Common Toxicity Criteria for Adverse Events version 3.0, and the primary endpoint was grade ≥2 RE within 6 months from the first treatment. LKB model parameters (n, m, and TD₅₀) were determined using maximum likelihood estimation. Overall performance of the model was quantified by Nagelkerke's R² and the scaled Brier score. Discriminative a

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10035357 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature