On-Demand Synthesis of Antiseptics at the Site of Infection for Treatment of Otitis Media.

ABSTRACT: Otitis media (OM) is the main reason for pediatric antibiotic prescriptions. The current treatment mandates a rigorous regimen of multidose antibiotics over 5-10 days. The systemic antibiotic exposure and often prematurely terminated treatment due to the challenge of drug administration to young patients are believed to breed antibiotic resistance. To address these challenges, we designed a local treatment that converted a metabolic product (H₂O₂) of an OM pathogen (Streptococcus pneumoniae) into a potent antiseptic (HOBr), a reaction catalyzed by locally administered vanadium pentoxide nanowires. The therapeutic, HOBr, was only synthesized in the presence of the pathogen, enabling on-demand generation of therapeutics for OM treatment. Hypohalous acids are broa

SUBMITTER: Lang J 

PROVIDER: S-EPMC10035358 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature