Onset timing and duration of augmented renal clearance in a mixed intensive care unit.

ABSTRACT:

Background

Augmented renal clearance (ARC) is associated with lower blood plasma concentrations of renally excreted drugs; however, its time course is unknown. The current study aimed to determine the onset timing/duration of ARC, its risk factors, and its association with clinical outcomes by continuous monitoring of urinary creatinine clearance (CrCl) in critically ill patients.

Methods

Data were retrospectively obtained from the medical records of 2592 critically ill patients admitted to the intensive care unit (ICU) from January 2019 to June 2022 at a tertiary emergency hospital. Among these, patients with continuously measured urinary CrCl were selected and observed over time. We evaluated the onset timing and duration of ARC by plotting Kaplan-Meier curves. Furthermore

SUBMITTER: Mikami R 

PROVIDER: S-EPMC10035487 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature