Ursodeoxycholic acid in the management of symptomatic gallstone disease: systematic review and clinician survey.

ABSTRACT:

Background

Symptomatic gallstones are common. Ursodeoxycholic acid (UDCA) is a bile acid that dissolves gallstones. There is increasing interest in UDCA for symptomatic gallstones, particularly in those unfit for surgery.

Method

A UK clinician survey of use and opinions about UDCA in symptomatic gallstones was performed, assessing clinicians' beliefs and perceptions of UDCA effectiveness. A systematic review was performed in accordance with the PRISMA guidelines. PubMed, MEDLINE, and Embase databases were searched for studies of UDCA for symptomatic gallstones (key terms included 'ursodeoxycholic acid'; 'UDCA'; 'biliary pain'; and 'biliary colic'). Information was assessed by two authors, including bias assessment, with independent review of conflicts.

Results

Overall

SUBMITTER: Hall L 

PROVIDER: S-EPMC10035564 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature