Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis.

ABSTRACT: The hallmark of tuberculosis (TB) is the formation of immune cell-enriched aggregates called granulomas. While granulomas are pathologically diverse, their tissue-wide heterogeneity has not been spatially resolved at the single-cell level in human tissues. By spatially mapping individual immune cells in every lesion across entire tissue sections, we report that in addition to necrotizing granulomas, the human TB lung contains abundant non-necrotizing leukocyte aggregates surrounding areas of necrotizing tissue. These cellular lesions were more diverse in composition than necrotizing lesions and could be stratified into four general classes based on cellular composition and spatial distribution of B cells and macrophages. The cellular composition of non-necrotizing structures also correlate

SUBMITTER: Sawyer AJ 

PROVIDER: S-EPMC10035589 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature