Maternal early life stress is associated with pro-inflammatory processes during pregnancy.

ABSTRACT: Early life stress (ELS) is common in the United States and worldwide, and contributes to the development of psychopathology in individuals with these experiences and their offspring. A growing body of research suggests that early life stress may contribute to adverse health partly through modulation of immune (and particularly inflammatory) responses. Therefore, increased maternal prenatal inflammation has been proposed as a mechanistic pathway by which the observed cross-generational effects of parental early life stress on child neuropsychiatric outcomes may be exerted. We examined associations between early life stress and molecular markers of inflammation (specifically pro-inflammatory gene expression and receptor-mediated transcription factor activity) and a commonly studied circulati

SUBMITTER: Mendez Leal AS 

PROVIDER: S-EPMC10035632 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature