Deciphering and Reversing Immunosuppressive Cells in the Treatment of Hepatocellular Carcinoma.

ABSTRACT: Use of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) has been partially successful. However, most HCC patients do not respond to immunotherapy. HCC has been shown to induce several immune suppressor mechanisms in patients. These suppressor mechanisms include involvement of myeloid-derived suppressor cells, regulatory T-cells, functionally impaired dendritic cells (DCs), neutrophils, monocytes, and tumor associated macrophages. The accumulation of immunosuppressive cells may lead to an immunosuppressive tumor microenvironment as well as the dense fibrotic stroma which may contribute to immune tolerance. Our laboratory has been investigating different cellular mechanisms of immune suppression in HCC patients. In vitro as well as in vivo studies have demo

SUBMITTER: Yu SJ 

PROVIDER: S-EPMC10035699 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature