Bootstrap, Bayesian probability and maximum likelihood mapping: exploring new tools for comparative genome analyses.

ABSTRACT:

Background

Horizontal gene transfer (HGT) played an important role in shaping microbial genomes. In addition to genes under sporadic selection, HGT also affects housekeeping genes and those involved in information processing, even ribosomal RNA encoding genes. Here we describe tools that provide an assessment and graphic illustration of the mosaic nature of microbial genomes.

Results

We adapted the Maximum Likelihood (ML) mapping to the analyses of all detected quartets of orthologous genes found in four genomes. We have automated the assembly and analyses of these quartets of orthologs given the selection of four genomes. We compared the ML-mapping approach to more rigorous Bayesian probability and Bootstrap mapping techniques. The latter two approaches appear to be more co

SUBMITTER: Zhaxybayeva O 

PROVIDER: S-EPMC100357 | biostudies-literature | 2002

REPOSITORIES: biostudies-literature