Diagnostic performance of serum exosomal miRNA-720 in hepatocellular carcinoma.

ABSTRACT:

Background/aim

Hepatocellular carcinoma (HCC) is associated with poor prognosis, largely due to late detection. Highly accurate biomarkers are urgently needed to detect early-stage HCC. Our study aims to explore the diagnostic performance of serum exosomal microRNA (miR)-720 in HCC.

Methods

Exosomal miRNA was measured via quantitative real-time PCR. A correlation analysis of exosomal miR-720 and tumor or clinico-demographic data of patients with HCC was performed. The receiver operating characteristic (ROC) curve was used to assess the diagnostic capacity of serum exosomal miR-720 for HCC, in comparison with α-fetoprotein (AFP) and prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II).

Results

MiR-720 was chosen as a potential HCC marker via miR microar

SUBMITTER: Jang JW 

PROVIDER: S-EPMC10035706 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature