Identification of circRNA-miRNA-mRNA regulatory network and its role in cardiac hypertrophy.

ABSTRACT:

Background

Hypertrophic cardiomyopathy (HCM) is a grave hazard to human health. Circular RNA (circRNAs) and micro RNA (miRNAs), which are competitive endogenous RNA, have been shown to play a critical role inHCM pathogenicity. However, to a great extent, the biological activities of ceRNA in HCM pathophysiology and prognosis remain to be investigated.

Materials and methods

By analyzing the expression files in the Gene Expression Comprehensive (GEO) database, differentially expressed (DE) circRNAs, miRNAs, and mRNAs in HCM were identified, and the target molecules of circRNAs and miRNAs were predicted. The intersection of the differentially expressed RNA molecules and the expected target was then calculated, and a ceRNA network was subsequently constructed using RNA molecules

SUBMITTER: Gong K 

PROVIDER: S-EPMC10035836 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature