Metastability as a candidate neuromechanistic biomarker of schizophrenia pathology.

ABSTRACT: The disconnection hypothesis of schizophrenia proposes that symptoms of the disorder arise as a result of aberrant functional integration between segregated areas of the brain. The concept of metastability characterizes the coexistence of competing tendencies for functional integration and functional segregation in the brain, and is therefore well suited for the study of schizophrenia. In this study, we investigate metastability as a candidate neuromechanistic biomarker of schizophrenia pathology, including a demonstration of reliability and face validity. Group-level discrimination, individual-level classification, pathophysiological relevance, and explanatory power were assessed using two independent case-control studies of schizophrenia, the Human Connectome Project Early Psychosis (HCP

SUBMITTER: Hancock F 

PROVIDER: S-EPMC10035891 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature