Potential molecular and cellular mechanisms for adverse placental outcomes in pregnancies complicated by SARS-CoV-2 infection-A scoping review.

ABSTRACT:

Background

Emerging evidence suggests that SARS-CoV-2 infection during pregnancy can result in placental damage and poor placental outcomes. However, the mechanisms by which SARS-CoV-2 infection leads to placental damage are not well understood. With a rapid expansion of literature on this topic, it is critical to assess the quality and synthesize the current state of literature. The objective of this scoping review is to highlight underlying mechanisms of SARS-CoV-2 mediated placental pathology in pregnant individuals and identify literature gaps regarding molecular and cellular mechanisms of poor placental outcomes.

Methods

The review was conducted and reported following the recommendations of the PRISMA extension for Scoping Reviews. The study protocol was registered with

SUBMITTER: Wai JY 

PROVIDER: S-EPMC10035918 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature