Clinical isolates of Candida auris with enhanced adherence and biofilm formation due to genomic amplification of ALS4.

ABSTRACT: Candida auris is an emerging multidrug-resistant fungal pathogen and a new global threat to human health. A unique morphological feature of this fungus is its multicellular aggregating phenotype, which has been thought to be associated with defects in cell division. In this study, we report a new aggregating form of two clinical C. auris isolates with increased biofilm forming capacity due to enhanced adherence of adjacent cells and surfaces. Unlike the previously reported aggregating morphology, this new aggregating multicellular form of C. auris can become unicellular after treatment with proteinase K or trypsin. Genomic analysis demonstrated that amplification of the subtelomeric adhesin gene ALS4 is the reason behind the strain's enhanced adherence and biofilm forming capacities. Many

SUBMITTER: Bing J 

PROVIDER: S-EPMC10035925 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature