Characterization of methylation profiles in spontaneous preterm birth placental villous tissue.

ABSTRACT: Preterm birth is a global public health crisis which results in significant neonatal and maternal mortality. Yet little is known regarding the molecular mechanisms of idiopathic spontaneous preterm birth, and we have few diagnostic markers for adequate assessment of placental development and function. Previous studies of placental pathology and our transcriptomics studies suggest a role for placental maturity in idiopathic spontaneous preterm birth. It is known that placental DNA methylation changes over gestation. We hypothesized that if placental hypermaturity is present in our samples, we would observe a unique idiopathic spontaneous preterm birth DNA methylation profile potentially driving the gene expression differences we previously identified in our placental samples. Our results in

SUBMITTER: Brockway HM 

PROVIDER: S-EPMC10035933 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature