Effects of irradiation on cumulative mortality in mice: shifting toward a younger age of death.

ABSTRACT: Recently, the question of whether cancer risk is only accelerated but not increased by radiation exposure has been raised. To explore this matter, we analyzed whether the cumulative mortality of irradiated mice could be explained by x-axis (age) shifted cumulative mortality of nonirradiated mice. We reanalyzed publicly available data on observed cumulative mortality or prevalence in irradiated female B6C3F1 mice that lived their entire lifespan. The results showed that the irradiated curve was well matched to uniformly shifted nonirradiated curve for the cumulative mortality of all causes of death but not for the cumulative mortality of all solid tumors and prevalence of ovarian tumors as is. After adjusting lifetime mortalities, it was also well matched for all solid and ovarian tumors. T

SUBMITTER: Fujimichi Y 

PROVIDER: S-EPMC10036085 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature