Coarsening dynamics can explain meiotic crossover patterning in both the presence and absence of the synaptonemal complex.

ABSTRACT: The shuffling of genetic material facilitated by meiotic crossovers is a critical driver of genetic variation. Therefore, the number and positions of crossover events must be carefully controlled. In Arabidopsis, an obligate crossover and repression of nearby crossovers on each chromosome pair are abolished in mutants that lack the synaptonemal complex (SC), a conserved protein scaffold. We use mathematical modelling and quantitative super-resolution microscopy to explore and mechanistically explain meiotic crossover pattering in Arabidopsis lines with full, incomplete, or abolished synapsis. For zyp1 mutants, which lack an SC, we develop a coarsening model in which crossover precursors globally compete for a limited pool of the pro-crossover factor HEI10, with dynamic

SUBMITTER: Fozard JA 

PROVIDER: S-EPMC10036115 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature