Longitudinal Lung Function Assessment of Patients Hospitalized With COVID-19 Using ¹H and ¹²⁹Xe Lung MRI.

ABSTRACT:

Background

Microvascular abnormalities and impaired gas transfer have been observed in patients with COVID-19. The progression of pulmonary changes in these patients remains unclear.

Research question

Do patients hospitalized with COVID-19 without evidence of architectural distortion on structural imaging exhibit longitudinal improvements in lung function measured by using ¹H and ¹²⁹Xe MRI between 6 and 52 weeks following hospitalization?

Study design and methods

Patients who were hospitalized with COVID-19 pneumonia underwent a pulmonary ¹H and ¹²⁹Xe MRI protocol at 6, 12, 25, and 51 weeks following hospital admission in a prospective cohort study between November 2020 and February 2022. The imaging protocol was as follows:

SUBMITTER: Saunders LC 

PROVIDER: S-EPMC10036146 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature