Memory-Based Prediction Deficits and Dorsolateral Prefrontal Dysfunction in Schizophrenia.

ABSTRACT:

Background

Theories suggest that people with schizophrenia (SZ) have problems generating predictions based on past experiences. The dorsolateral prefrontal cortex (DLPFC) and hippocampus participate in memory-based prediction. We used functional magnetic resonance imaging to investigate DLPFC and hippocampal function in healthy control (HC) subjects and people with SZ during memory-based prediction.

Methods

Prior to scanning, HC subjects (n = 54) and people with SZ (n = 31) learned 5-object sequences presented in fixed or random orders on each repetition. During scanning, participants made semantic decisions (e.g., "Can this object fit in a shoebox?") on a continuous stream of objects from fixed and random sequences. Sequence prediction was demonstrated by faster semantic de

SUBMITTER: Williams AB 

PROVIDER: S-EPMC10036169 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature