Decellularization compromises mechanical and structural properties of the native trachea.

ABSTRACT: Tracheal replacement using tissue engineering technologies offers great potential to improve previously intractable clinical interventions, and interest in this area has increased in recent years. Many engineered airway constructs currently rely on decellularized native tracheas to serve as the scaffold for tissue repair. Yet, mechanical failure leading to airway narrowing and collapse remains a major cause of morbidity and mortality following clinical implantation of decellularized tracheal grafts. To understand better the factors contributing to mechanical failure in vivo, we characterized the histo-mechanical properties of tracheas following two different decellularization protocols, including one that has been used clinically. All decellularized tracheas deviated from native mec

SUBMITTER: Greaney AM 

PROVIDER: S-EPMC10036236 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature