Sex differences in risk factors for end-stage kidney disease and death in type 2 diabetes: A retrospective cohort study.

ABSTRACT:

Background

This study investigated the sex differences in the risk of end-stage kidney disease (ESKD) and mortality, as well as the effect modification of sex on associated factors in patients with type 2 diabetes.

Methods

This multicenter observational cohort study included 4328 patients with type 2 diabetes. Hazard ratios (HRs) with 95% confidence intervals (CIs) of sex for ESKD and death were estimated using Cox proportional regression with adjustment for baseline covariates. For assessing risk modification, HRs and incidence rates for ESKD and death were compared between sexes across patient characteristics using Cox proportional and Poisson regression models.

Results

During a median follow-up of 7 years, 276 patients (70% men) developed ESKD, and 241 patients (68

SUBMITTER: Oshima M 

PROVIDER: S-EPMC10036257 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature