Clinical and genomic characterization of Chinese patients with functional high-risk multiple myeloma: A real-world validation study.

ABSTRACT:

Objective

Precise risk stratification is increasingly essential in the management of multiple myeloma (MM) as some standard-risk (SR) patients still exhibit similar poor outcomes as genetically high-risk (GHR) patients in the era of novel agents. It has recently been demonstrated that functional high-risk (FHR) patients, those with suboptimal response to first-line induction therapy or early relapse within 12 months, have identifiable molecular characteristics from the SR group in the CoMMpass dataset. However, these findings lack practical validation in the real world.

Methods

MM cells purified by CD138 microbeads from newly diagnosed MM (NDMM) patients received fluorescence in situ hybridization and sequencing with a 92-gene Panel. Cytogenetic abnormalities defined

SUBMITTER: Wang YT 

PROVIDER: S-EPMC10036342 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature