Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea.

ABSTRACT: Objectives: Some ceRNA associated with lncRNA have been considered as possible diagnostic and therapeutic biomarkers for obstructive sleep apnea (OSA). We intend to identify the potential hub genes for the development of OSA, which will provide a foundation for the study of the molecular mechanism underlying OSA and for the diagnosis and treatment of OSA. Methods: We collected plasma samples from OSA patients and healthy controls for the detection of ceRNA using a chip. Based on the differential expression of lncRNA, we identified the target genes of miRNA that bind to lncRNAs. We then constructed lncRNA-related ceRNA networks, performed functional enrichment analysis and protein-protein interaction analysis, and performed internal and external validation of the expression le

SUBMITTER: Liu W 

PROVIDER: S-EPMC10036397 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature